Single beam acoustic tweezers for biomedical applications

Hae Gyun Lim

doi:10.7776/ASK.2023.42.5.452

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2023 Vol.42, Issue 5 Preview Page Next Page

Research Article

Single beam acoustic tweezers for biomedical applications 단일 빔 음향 집게를 이용한 바이오메디컬 응용 연구

30 September 2023. pp. 452-459

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Abstract

Acoustic tweezers represent an exceptionally versatile and adaptable collection of instruments that harness the intrinsic power of sound waves to manipulate a wide spectrum of bioparticles, ranging from minuscule extracellular vesicles at the nanoscale to more substantial multicellular organisms measuring in millimeters. This field of research has witnessed remarkable progress over the course of the past few decades, primarily in the domain of Single Beam Acoustic Tweezers (SBAT) which utilizes a single element transducer for its operation. Initially conceived as a method for particle trapping, SBAT has since evolved into an advanced platform capable of achieving precise translation of cells and organisms. Recent groundbreaking advancements have significantly enhanced the capabilities of SBAT, unlocking new functionalities such as particle/cell separation and controlled deformation of single cells. These advancements have propelled SBAT to the forefront of bioparticle/cell manipulation, gathering attention within the scientific community. This review explores the core principles of SBAT and how sound waves affect bioparticles/cells. We aim to build a strong conceptual foundation for understanding advancements in this field by detailing its principles and methodologies.

Keywords

Ultrasound

Acoustics

Acoustic tweezers

Single beam acoustic tweezers

Cell manipulation

Cell deformation

음파의 힘을 이용하는 음향집게는 나노 단위의 세포외소포에서 밀리미터 단위의 대규모 다세포생 물체까지 다양한 생체 입자를 조작하는 데 사용되는 매우 유용한 도구이다. 해당 분야는 수십년간 점진적인 개발이 이루어지고 있으며, 단일 초음파 빔을 사용하는 단일 빔 음향 집게(Single Beam Acoustic Tweezers, SBAT)기술 또한 세포 및 생물체 정밀 이동 및 분석이 가능한 플랫폼으로 발전했다. 최근 혁신적인 발전으로 SBAT를 이용하여 입자/세포 분리, 단일 세포 변형 기술이 개발되었으며 이로 인해 의공학 분야에서 학문적인 관심을 모으고 있다. 본 종설에서 SBAT기술의 기초 원리와 작동 방법에 대해서 설명하며 그간의 연구를 요약하고 이를 바탕으로 향후 연구에 대해서 전망한다.

키워드

초음파

음향학

음향 집게

단일 빔 음향 집게

세포 조정

세포 변형

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Information

Publisher :The Acoustical Society of Korea
Publisher(Ko) :한국음향학회
Journal Title :The Journal of the Acoustical Society of Korea
Journal Title(Ko) :한국음향학회지
Volume : 42
No :5
Pages :452-459
Received Date : 2023-06-30
Accepted Date : 2023-08-31
DOI :https://doi.org/10.7776/ASK.2023.42.5.452

The Journal of the Acoustical Society of Korea 한국음향학회지 ISSN:1225-4428(Print) 2287-3775(Online)

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