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2013 Vol.32, Issue 2 Preview Page
Effect of Cortical Bone on Acoustic Properties of Trabecular Bone in Bovine Femur In Vitro

생체 외 조건의 소 대퇴골에서 해면질골의 음향특성에 대한 피질골의 효과

Kyo Seung Hwang1
,
Kang Il Lee1*
황 교승1
,
이 강일1*
1강원대학교 물리학과
*Corresponding Author
31 March 2013. pp. 181-189
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Abstract

The purpose of the present study is to investigate the effect of cortical bone on acoustic properties of trabecular bone, such as speed of sound (SOS) and normalized broadband ultrasound attenuation (nBUA), in bovine femur in vitro. Twelve trabecular bone samples and three cortical bone plates with thicknesses of 1.00, 1.47, and 2.00 mm were extracted from the proximal end of two bovine femurs. The correlations between acoustic properties and trabecular apparent bone density were also examined before and after attaching a cortical bone plate to the trabecular bone samples. SOS increased linearly with increasing thickness of the cortical plate attached to one side of ultrasonic incidence of the trabecular bone samples, whereas nBUA showed a nonlinear dependence on the thickness of the cortical plate. All the SOS (r = 0.95-0.97) and nBUA (r = 0.53-0.73) measurements with and without the cortical bone plate with various thicknesses were found to exhibit high correlations with the trabecular apparent bone density. These results imply that the acoustic properties measured in the femur with lateral cortical layers in vitro can be useful indices for the prediction of trabecular bone mineral density.

Keywords
Osteoporosis
Femur
Trabecular bone
Cortical bone
Quantitative ultrasound
Speed of sound
Broadband ultrasound attenuation

본 연구의 목적은 생체 외 조건의 소 대퇴골에서 피질골이 해면질골의 음속(SOS) 및 광대역 초음파 감쇠 (nBUA)와 같은 음향특성에 미치는 효과를 조사하는 것이다. 이를 위해 2개의 소 대퇴골을 이용하여 근위부로부터 12개의 해면질골 샘플 및 1.00, 1.47, 및 2.00 mm의 두께를 갖는 3개의 피질골 판을 제작하였다. 또한 해면질골 샘플에 피질골 판 부착 전후 측정된 음향특성과 해면질골 겉보기 골밀도 사이의 상관관계를 조사하였다. 해면질골 샘플의 초음파 입사면에 부착된 피질골 판의 두께가 증가함에 따라 SOS는 선형적으로 증가하는 반면에 nBUA는 피질골 판의 두께에 대해 비선형적인 의존성을 나타내는 것을 알 수 있었다. 또한 서로 다른 두께를 갖는 피질골 판이 부착되더라도 SOS(r = 0.95-0.97) 및 nBUA(r = 0.53-0.73)와 해면질골 겉보기 골밀도 사이의 높은 상관관계는 유지되는 것을 알 수 있었다. 이와 같은 결과는 생체 외 조건의 피질골이 제거되지 않은 대퇴골에서 측정된 음향특성이 해면질골의 골밀도를 예측하기에 충분한 지표라는 것을 의미한다.

키워드
골다공증
대퇴골
해면질골
피질골
정량적 초음파
음속
광대역 초음파 감쇠
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Information
  • Publisher :The Acoustical Society of Korea
  • Publisher(Ko) :한국음향학회
  • Journal Title :The Journal of the Acoustical Society of Korea
  • Journal Title(Ko) :한국음향학회지
  • Volume : 32
  • No :2
  • Pages :181-189
  • Received Date : 2012-11-12
  • Accepted Date : 2012-12-28
  • DOI :https://doi.org/10.7776/ASK.2013.32.2.181
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