Correlations between Acoustic Properties and Bone Mineral Density in Bovine Femoral Trabecular Bone In Vitro

Kyo Seung Hwang; Dong-Wan Seo; Kang Il Lee

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2012 Vol.31, Issue 4 Preview Page Next Page

Correlations between Acoustic Properties and Bone Mineral Density in Bovine Femoral Trabecular Bone In Vitro 생체 외 조건의 소 대퇴골 해면질골에서 음향특성과 골밀도 사이의 상관관계

31 May 2012. pp. 244-252

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Abstract

The purpose of the present study is to investigate the correlations between acoustic properties, such as speed of sound and normalized broadband ultrasound attenuation, and bone mineral density in femur with high fracture risk. The speed of sound and the normalized broadband ultrasound attenuation in 15 bovine femoral trabecular bone samples in vitro were measured by using a through-transmission method with two matched pairs of ultrasonic transducers with center frequencies of 0.5 and 1.0 MHz. The volumetric bone mineral density of the trabecular bone samples was measured by using micro-computed tomography. The bone mineral density exhibited strong correlations with both the speed of sound and the normalized broadband ultrasound attenuation measured by using the 0.5 and the 1.0 MHz transducers. The highest correlation was found between the bone mineral density and the normalized broadband ultrasound attenuation measured by using the 0.5 MHz ultrasonic transducers. The results suggest that the acoustic properties measured in the femur in vitro can be used as indices for the prediction of femoral bone mineral density.

Keywords

Osteoporosis

Femur

Trabecular bone

Bone mineral density

Quantitative ultrasound

Speed of sound

Broadband ultrasound attenuation

본 연구의 목적은 골절 위험도가 높은 대퇴골에서 음속 및 광대역 초음파 감쇠와 같은 음향특성과 골밀도 사이의 상관관계를 조사하는 것이다. 이를 위해 0.5 및 1.0 MHz의 중심주파수를 갖는 두 쌍의 초음파 트랜스듀서와 함께 투과법을 이용하여 생체 외 조건에서 15개의 소 대퇴골 해면질골 샘플의 음속 및 광대역 초음파 감쇠를 측정하였다. 또한 마이크로 컴퓨터 단층촬영법을 이용하여 해면질골 샘플의 단위체적당 골밀도를 측정하였다. 골밀도는 0.5 및 1.0 MHz 초음파 트랜스듀서를 이용하여 측정된 음속 및 광대역 초음파 감쇠와 모두 강한 상관관계를 나타냈으며, 골밀도와 0.5 MHz 초음파 트랜스듀서를 이용하여 측정된 광대역 초음파 감쇠 사이에 가장 높은 상관관계가 존재하였다. 이와 같은 결과는 생체 외 조건의 대퇴골에서 측정된 음향특성이 대퇴골의 골밀도를 예측하기에 충분한 지표라는 것을 의미한다.

키워드

골다공증

대퇴골

해면질골

골밀도

정량적 초음파

음속

광대역 초음파 감쇠

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Information

Publisher :The Acoustical Society of Korea
Publisher(Ko) :한국음향학회
Journal Title :The Journal of the Acoustical Society of Korea
Journal Title(Ko) :한국음향학회지
Volume : 31
No :4
Pages :244-252
Received Date : 2012-02-02
Revised Date : 2012-02-29
Accepted Date : 2012-03-13

The Journal of the Acoustical Society of KoreaISSN:1225-4428(Print) 2287-3775(Online)한국음향학회

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