Correlation analysis of antipsychotic dose and speech characteristics according to extrapyramidal symptoms

Subin Lee; Seoyoung Kim; Hye Yoon Kim; Euitae Kim; Kyung-Sang Yu; Ho-Young Lee; Kyogu Lee

doi:10.7776/ASK.2022.41.3.367

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2022 Vol.41, Issue 3 Preview Page

Research Article

Correlation analysis of antipsychotic dose and speech characteristics according to extrapyramidal symptoms 추체외로 증상에 따른 항정신병 약물 복용량과 음성 특성의 상관관계 분석

31 May 2022. pp. 367-374

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Abstract

In this paper, correlation analysis between speech characteristics and the dose of antipsychotic drugs was performed. To investigate the pattern of speech characteristics of ExtraPyramidal Symptoms (EPS) related to voice change, a common side effect of antipsychotic drugs, a Korean-based extrapyramidal symptom speech corpus was constructed through the sentence development. Through this, speech patterns of EPS and non-EPS groups were investigated, and in particular, a strong speech feature correlation was shown in the EPS group. In addition, it was confirmed that the type of speech sentence affects the speech feature pattern, and these results suggest the possibility of early detection of antipsychotics-induced EPS based on the speech features.

Keywords

ExtraPyramidal Symptoms (EPS)

Antipsychotic drugs

Speech characteristics

Speech corpus

본 논문은 항정신병 약물의 복용량에 따른 음성 특징의 상관관계 분석을 수행하였다. 항정신병 약물의 대표적 부작용 중 하나인 추체외로 증상(ExtraPyramidal Symptoms, EPS) 발생에 따른 음성 특징의 패턴을 알아보기 위하여, 문장 개발을 통해 한국어 기반 추체외로 증상 음성 코퍼스를 구축하였다. 수집된 자료는 추체외로 증상 군과 비 추체외로 증상 군으로 나누어 음성 특징 패턴을 조사하였으며, 특히 추체외로 증상 군의 높은 음성 특징 상관관계를 보였다. 또한, 발화 문장의 종류가 음성 특징 패턴에 영향을 미친다는 것을 확인할 수 있었으며, 이를 통해 음성 특징을 기반한 추체외로 증상의 조기 발견 가능성을 기대해볼 수 있었다.

키워드

추체외로 증상

항정신병 약물

음성 특징

음성 코퍼스

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Information

Publisher :The Acoustical Society of Korea
Publisher(Ko) :한국음향학회
Journal Title :The Journal of the Acoustical Society of Korea
Journal Title(Ko) :한국음향학회지
Volume : 41
No :3
Pages :367-374
Received Date : 2022-03-21
Revised Date : 2022-05-10
Accepted Date : 2022-05-24
DOI :https://doi.org/10.7776/ASK.2022.41.3.367

The Journal of the Acoustical Society of Korea ISSN:1225-4428(Print) 2287-3775(Online) 한국음향학회지

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