Thermal distribution change in polyvinyl alcohol gel caused by focused ultrasound

Jungsoon Kim; Moojoon Kim

doi:10.7776/ASK.2020.39.6.576

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2020 Vol.39, Issue 6 Preview Page Next Page

Research Article

Thermal distribution change in polyvinyl alcohol gel caused by focused ultrasound 폴리비닐알코올 젤의 집속초음파에 의한 온도분포 변화

30 November 2020. pp. 576-584

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Abstract

In order to obtain basic information for using polyvinyl alcohol (PVA) gel as a tissue mimicking phantom for temperature visualization, the temperature change characteristics due to the focused ultrasound were examined for different concentration of PVA. To obtain the basic acoustic characteristics, the speed of sound, the attenuation coefficient, and the density depending on the PVA concentration were measured, and the thermodynamic characteristics, such as thermal conductivity and heat capacity, were measured. The range of temperature rising in the vicinity of the focal point due to the focused ultrasound was observed using a thermochromic film that changes color at 30 degree or more, and the discolored area was obtained by image processing of the recorded image. As the concentration of PVA increases in the given range of 2 wt% ~ 16 wt%, the area that rises above 30 degree inside the gel increases linearly. It is confirmed that the discolored area increases as the power applied to the focused ultrasonic transducer increases. These results showed good agreement with the simulation results using the finite element method.

Keywords

Focused ultrasound

Polyvinyl alcohol gel

Thermal distribution

Thermochromic film

Ultrasonic transducer

Temperature visualization

폴리비닐알코올(polyvinyl alcohol, PVA)젤을 온도가시화용 생체모의매질로 사용하기 위한 기초적인 정보를 얻기 위하여, PVA의 농도를 바꾸어가며 집속초음파에 의한 온도변화 특성을 조사하였다. 기본적인 음향 특성을 조사하기 위하여 PVA농도에 따른 음속, 감쇠계수, 밀도 등이 측정되었고 열역학적 특성인 열전도도, 열용량이 측정되었다. 30 °C 이상에서 변색되는 시온필름을 사용하여 집속초음파에 의해 상승되는 초점부근의 온도 변화의 범위를 관찰하였으며 기록된 이미지의 화상처리를 통하여 변색범위의 면적을 도출하였다. PVA의 농도가 2 wt% ~16 wt%의 범위에서 증가할수록 젤 내부에서 30 °C 이상으로 상승하는 영역은 선형적으로 증가함을 보였고 집속초음파 트랜스듀서에 인가하는 파워가 증가할수록 변색영역이 증가함을 확인하였다. 이들 결과는 유한요소법을 사용한 시뮬레이션 결과와도 좋은 일치를 보였다.

키워드

집속초음파

폴리비닐알코올 젤

온도분포

시온필름

초음파 트랜스듀서

온도가시화

References

Q. Cheng, S. Wang, T. Rials, and S. Lee, "Physical and mechanical properties of polyvinyl alcohol and polypropylene composite materials reinforced with fibril aggregates isolated from regenerated cellulose fibers," Cellulose, 14, 593-602 (2007). 10.1007/s10570-007-9141-0

S. Gupta, A. Pramanik, A.Kailath, T. Mishra, A. Guha, S. Nayar, and A. Sinha, "Composition dependent structural modulations in transparent poly(vinyl alcohol) hydrogels," Colloids and Surfaces B: Biointerfaces 74, 186-190 (2009). 10.1016/j.colsurfb.2009.07.01519700267

B. Gajra, S. Pandya, G. Vidyasagar, H. Rabari, R. Dedania, and S. Rao, "Poly vinyl alcohol hydrogel and its pharmaceutical and biomedical applications: A review," Int. J. Pharm. Sci. Res. 4, 20-26 (2012).

K. Funamoto, T. Hayase, Y. Saijo, and T. Yambe, "Numerical experiment of transient and steady characteristics of ultrasonic-measurement-integrated simulation in three-dimensional blood flow analysis," Ann. Biomed. Eng. 37, 34-49 (2009). 10.1007/s10439-008-9600-219011966

K. Funamoto, T. Hayase, Y. Saijo, and T. Yambe, "Numerical analysis of effects of measurement errors on ultrasonici-measurement-integrated simulation," IEEE Trans. Biomed. Eng. 58, 653-663 (2011). 10.1109/TBME.2010.209541821118762

O. Yamashita, K. Funamoto, and T. Hayase, "Development of poly (vinyl alcohol) gel with in vivo acoustic properties," Proc. of the 21st Bioengineering Conference 2009 meeting, 451-452 (2009). 10.1299/jsmebio.2008.21.451

K. Hayakawa. S. Takeda, K. Kawabe, and T. Shimura, "Acoustic characteristics of pva gel," IEEE Int. Ultrason. Symp. 969-972 (1989).

B. Gajra, S. Pandya, G. Vidyasagar, H. Rabari, R. Dedania, and S. Rao, "Polyvinyl alcohol hydrogel and its pharmaceutical and biomedical applications: A review," Int. J. Pharm. Sci. Res. 4, 20-26 (2012).

M. Choi, S. Guntur, K. Lee, D. Paeng, and A. Coleman, "A tissue mimicking polyacrylamide hydrogel phantom for visualizing thermal lesions generated by high intensity focused ultrasound," Ultrasound Med. Biol. 39, 439-448 (2013). 10.1016/j.ultrasmedbio.2012.10.00223312531

A. Maxwell, T. Wang, L. Yuan, A. Duryea, Z. Xu, and C. Cain, "A tissue phantom for visualization and measurement of ultrasound-induced cavitation damage," Ultrasound Med. Biol. 36, 2132-2143 (2010). 10.1016/j.ultrasmedbio.2010.08.02321030142PMC2997329

C. Lafon, V. Zderic, M. Noble, J. Yuen, P. Kaczkowski, O. Sapozhnikov, F. Chavrier, L. Crum, and S. Vaezy, "Gel phantom for use in high-intensity focused ultrasound dosimetry," Ultrasound Med. Biol. 31, 1383- 1389 (2005). 10.1016/j.ultrasmedbio.2005.06.00416223642

J. Kim, M. Kim, Y. Park, and K. Ha, "Acoustic Characteristics of a tissue mimicking phantom for visualization of thermal distribution," Jpn. J. Appl. Phys. 51, 07GB10 (2012). 10.7567/JJAP.51.07GB10

J. Kim, J. Jung, M. Kim, and K. Ha, "Experimental analysis of temperature elevation in ultrasonic beam from circular piston," Jpn. J. Appl. Phys. 53, 07KF14 (2014). 10.7567/JJAP.53.07KF14

J. Kim, J. Jung, M. Kim, and K. Ha, "Visualization of temperature elevation due to focused ultrasound generated by tone bursts wave," Jpn. J. Appl. Phys. 53, 07KF16 (2014). 10.7567/JJAP.53.07KF16

J. Kim, J. Jung, M. Kim, and K. Ha, "Estimation of thermal distribution in tissue mimicking phantom made of carrageenan gel," Jpn. J. Appl. Phys. 54, 07HF23 (2015). 10.7567/JJAP.54.07HF23

J. Kim, J. Jung, M. Kim, E. Lee, and I. Lee, and K. Ha, "Distribution of temperature elevation caused by moving HIFU transducer," Jpn. J. Appl. Phys. 54, 07HF13 (2015). 10.7567/JJAP.54.07HF13

J. Jung, J. Kim, K. Ha, M. Kim, and Y. Cao, "Tissue mimicking phantom for visualization of temperature elevation caused by ultrasound" (in Korean), J. Acoust. Soc. Kr. 33, 291-299 (2014). 10.7776/ASK.2014.33.5.291

X. Fan and K. Hynynen, "The effect of wave reflection and refraction at soft tissue interfaces during ultrasound hyperthermia treatments," J. Acoust. Soc. Am. 91, 1727-1736 (1992). 10.1121/1.4024521564208

R. Martinez, A. Vera, and L. Leija, "HIFU induced heating modelling by using the finite element method," Phys. Procedia, 63, 127-133 (2015). 10.1016/j.phpro.2015.03.021

S. Tanaka, K. Shimizu, S. Sakuma, T. Tsuchiya, and N. Endoh, "Experimental and numerical analysis of temperature rise in phantom caused by high-intensity focused ultrasonic irradiation," Jpn. J. Appl. Phys. 52, 07HF09 (2013). 10.7567/JJAP.52.07HF09

W. Nyborg, "Solutions of the bio-heat transfer equation," Phys. Med. Bioi. 33, 785-792 (1988). 10.1088/0031-9155/33/7/0023212041

U. Kaatze, K. Lautscham, and M. Brai, "Acoustical absorption spectroscopy of liquids between 0.15 and 3000 MHz: II. ultrasonic pulse transmission methods," J. Phys. E: Sci. Instrum. 21, 98-103 (1988). 10.1088/0022-3735/21/1/018

J. Kim, J. Kim, M. Kim, K. Ha, and A. Yamada, "Arrayed ultrasonic transducers on arc surface for plane wave synthesis," Jpn. J. Appl. Phys. 43, 3061- 3062 (2004). 10.1143/JJAP.43.3061

C. H. Sherman and J. L. Butler, Transducers and Arrays for Underwater Sound (Springer, New York, 2008), Chap. 12. 10.1007/978-0-387-33139-3

Information

Publisher :The Acoustical Society of Korea
Publisher(Ko) :한국음향학회
Journal Title :The Journal of the Acoustical Society of Korea
Journal Title(Ko) :한국음향학회지
Volume : 39
No :6
Pages :576-584
Received Date : 2020-08-20
Revised Date : 2020-10-05
Accepted Date : 2020-10-13
DOI :https://doi.org/10.7776/ASK.2020.39.6.576

The Journal of the Acoustical Society of Korea ISSN:1225-4428(Print) 2287-3775(Online) 한국음향학회지

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