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2020 Vol.39, Issue 1 Preview Page

Research Article

High-intensity focused ultrasound beam path visualization using ultrasound imaging

초음파 영상을 이용한 고강도 집중 초음파 빔 시각화

Jae Hee Song1
,
Jin Ho Chang2
,
Yang Mo Yoo2∗
송 재희1
,
장 진호2
,
유 양모2∗
1Queenland Brain Institute, University of Queenland
2Departments of Electronic Engineering and Biomedical Engineering, Sogang University
∗Corresponding Author
31 January 2020. pp. 16-23
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Abstract

In High-Intensity Focused Ultrasound (HIFU) treatment, effective localization of HIFU focus is important for developing a safe treatment plan. While Magnetic Resonance Imaging guided HIFU (MRIgHIFU) can visualize the ultrasound path during the treatment for localizing HIFU focus, it is challenging in ultrasound imaging guided HIFU (USIgHIFU). In the present study, a real-time ultrasound beam visualization technique capable of localizing HIFU focus is presented for USIgHIFU. In the proposed method, a short pulse, with the same center frequency of an imaging ultrasound transducer below the regulated acoustic intensity (i.e., Ispta < 720 mW/cm2), was transmitted through a HIFU transducer whereupon backscattered signals were received by the imaging transducer. To visualize the HIFU beam path, the backscattered signals underwent dynamic receive focusing and subsequent echo processing. From in vitro experiments with bovine serum albumin gel phantoms, the HIFU beam path was clearly depicted with low acoustic intensity (i.e., Ispta of 94.8 mW/cm2) and the HIFU focus was successfully localized before any damages were produced. This result indicates that the proposed ultrasound beam path visualization method can be used for localizing the HIFU focus in real time while minimizing unwanted tissue damage in USIgHIFU treatment.

Keywords
High-intensity focused ultrasound
Ultrasound image guidance
Focal point position
Ultrasound beam path

고강도 집중 초음파(High-Intensity Focused Ultrasound, HIFU) 치료에서 HIFU 초점의 효과적인 위치 파악은 안전한 치료 계획을 개발하는 데 중요하다. 자기 공명 영상 유도 HIFU(Magnetic Resonance Imaging guided HIFU, MRIgHIFU)는 HIFU 초점을 영상화하여 치료 중에 초음파 경로를 시각화 할 수 있지만 초음파 이미징 유도 HIFU (Ultrasound imaging guided HIFU, USIgHIFU)에서는 어려움이 있다. 본 연구에서는 USIgHIFU에 대해 HIFU 초점을 영상화할 수 있는 실시간 초음파 빔 시각화 기법을 제시 하였다. 제안 된 방법에서, 음향 강도(Ispta < 720 mW/cm2) 아래의 이미징 초음파 변환자의 동일한 중심 주파수를 갖는 짧은 펄스가 HIFU 변환기를 통해 전송되고, HIFU 빔 경로를 시각화하기 위해 수신 신호는 동적 수신 포커싱 및 후속 에코 처리를 거쳤다. 소 혈청 알부민 젤 팬텀을 이용한 생체 외 실험으로부터, HIFU 빔 경로는 낮은 음향 강도 (Ispta = 94.8 mW/cm2)에서도 명확히 영상화 할 수 있었고 HIFU 초점은 손상이 생성되기 전에 성공적으로 시각화하였다. 이 결과는 제안 된 초음파 빔 경로 시각화 방법이 USIgHIFU 치료에서 원치 않는 조직 손상을 최소화하면서 실시간으로 HIFU 초점을 영상화하는 데 사용될 수 있음을 나타낸다.

키워드
고강도 집중 초음파
초음파 이미징 유도 치료
초점 위치 파악
초음파 빔 경로
References
1
G. ter Haar, "Therapeutic ultrasound," Eur. J. Ultrasound, 9, 3-9 (1999).
10.1016/S0929-8266(99)00013-0
2
G. ter Haar, "High intensity ultrasound," Surg. Innov. 8, 77-89 (2001).
10.1053/slas.2001.2440211337740
3
J. E. Kennedy, "High-intensity focused ultrasound in the treatment of solid tumours," Nat. Rev. Cancer, 5, 321-327 (2005).
10.1038/nrc159115776004
4
D. Arora, D. Cooley, T. Perry, M. Skliar, and R. B. Roemer, "Direct thermal dose control of constrained focused ultrasound treatments: phantom and in vivo evaluation," Phys. Med. Biol. 50, 1919-1935 (2005).
10.1088/0031-9155/50/8/01915815104PMC3703954
5
J. Seo, B. C. Tran, T. L. Hall, J. B. Fowlkes, G. B. Abrams, M. O'Donnell, and C. A. Cain, "Evaluation of ultrasound tissue damage based on changes in image echogenicity in canine kidney," IEEE Trans. Ultrason. Ferroelect. Freq. Contr. 52, 1111-1120 (2005).
10.1109/TUFFC.2005.150399716212250
6
S. Vaezy, X. Shi, R. W. Martin, E. Chi, P. I. Nelson, M. R. Bailey, and L. A. Crum, "Real-time visualization of high-intensity focused ultrasound treatment using ultrasound imaging," Ultrasound Med. Biol. 27, 33-42 (2001).
10.1016/S0301-5629(00)00279-9
7
R. Catane, A. Beck, Y. Inbar, T. Rabin, N. Shabshin, S. Hengst, R. M. Pfeffer, A. Hanannel, O. Dogadkin, B. Liberman, and D. Kopelman, "MR-guided focused ultrasound surgery (MRgFUS) for the palliation of pain in patients with bone metastases - preliminary clinical experience," Ann. Oncol. 18, 163-167 (2007).
10.1093/annonc/mdl33517030549
8
O. Esnault, B. Franc, J. P. Monteil, and J. Y. Chapelon, "High-intensity focused ultrasound for localized thyroid-tissue ablation: Preliminary experimental animal study," Thyroid, 14, 102-1076 (2004).
10.1089/thy.2004.14.107215650361
9
H. Furusawa, K. Namba, H. Nakahara, C. Tanaka, Y. Yasuda, E. Hirabara, M. Imahariyama, and K. Komaki, "The evolving non-surgical ablation of breast cancer: MR guided focused ultrasound (MRgFUS)," Breast Cancer, 14, 55-58 (2007).
10.2325/jbcs.14.5517244995
10
J. H. Hwang and L. A. Crum, "Current status of clinical high-intensity focused ultrasound," Proc. the 31st Annual International Conference of the IEEE EMBS. Minneapolis, MN, USA, 130-133 (2008).
11
J. E. Kennedy and G. ter Haar, and D. Cranston, "High intensity focused ultrasound: surgery of the future?" Br. J. Radiol. 76, 590-599 (2003).
10.1259/bjr/1715027414500272
12
J. E. Kennedy, F. Wu, G. ter Haar, F. V. Gleeson, R. R. Phillips, M. R. Middleton, and D. Cranston, "High-intensity focused ultrasound for the treatment of liver tumours," Ultrasonics, 42, 931-935 (2004).
10.1016/j.ultras.2004.01.08915047409
13
S. Madersbacher, M. Pedevilla, L. Vingers, M. Susani, and M. Marberger, "Effect of high-intensity focused ultrasound on human prostate cancer in vivo," Cancer Res. 55, 3346-3351 (1995).
14
E. A. Stewart, J. Rabinovici, C. M. C. Tempany, Y. Inbar, L. Regan, B. Gastout, G. Hesley, H. S. Kim, S. Hengst, and W. M. Gedroye, "Clinical outcomes of focused ultrasound surgery for the treatment of uterine fibroids," Fertil. Steril. 85, 22-29 (2006).
10.1016/j.fertnstert.2005.04.07216412721
15
F. Wu, Z. B. Wang, W. Z. Chen, J. Bai, H. Zhu, and T. Y. Qiao, "Preliminary experience using high intensity focused ultrasound for the treatment of patients with advanced stage renal malignancy," J. Urol. 170, 2237-2240 (2003).
10.1097/01.ju.0000097123.34790.7014634387
16
F. Wu, Z. B. Wang, W. Z. Chen, J. Z. Zou, J. Bai, H. Zhi, K. Q. Li, F. L. Xie, C. B. Jin, H. B. Su, and G. W. Gao, "Extracorporeal focused ultrasound surgery for treatment of human solid carcinomas: early Chinese clinical experience," Ultrasound Med. Biol. 30, 245-260 (2004).
10.1016/j.ultrasmedbio.2003.10.01014998677
17
L. L. Xiong, J. H. Hwang, X. B. Huang, S. S. Yao, C. J. He, X. H. GE, H. Y. Ge, and X. F. Wang, "Early clinical experience using high intensity focused ultrasound for palliation of inoperable pancreatic cancer," JOP J. Pancreas, 10, 123-129 (2009).
18
C. C. Wu, C. N. Chen, M. C. Ho, W. S. Chen, and P. H. Lee, "Using the acoustic interference pattern to locate the focus of a high-intensity focused ultrasound (HIFU) transducer," Ultrasound Med. Biol. 34, 137-146 (2008).
10.1016/j.ultrasmedbio.2007.07.00117720300
19
X. Zheng and S. Vaezy, "An acoustic backscatter-based method for localization of lesions induced by high-intensity focused ultrasound," Ultrasound Med. Biol. 36, 610-622 (2010).
10.1016/j.ultrasmedbio.2010.01.00120211516
20
J. Hindley, W. M. Gedroyc, L. Regan, E. Stewart, C. Tempany, K. Hynnen, N. Macdanold, Y. Inbar, Y. Itzchak, J. Rabinovici, K. Kim, J. F. Geschwind, G. Hesley, B. Gostout, T. Ehrenstein, S. Hengst, M. Sklair-Levy, A. Shushan, and F. Jolesz, "MRI guidance of focused ultrasound therapy of uterine fibroids: Early results," Am. J. Roentgenol. 183, 1713-1719 (2004).
10.2214/ajr.183.6.0183171315547216
21
N. McDannold, C. M. Tempany, F. M. Fennessy, M. J. So, F. J. Rybicki, E. A. Stewart, F. A. Jolesz, and K. Hynynen, "Uterine Leiomyomas: MR imaging-based thermometry and thermal dosimetry during focused ultrasound thermal ablation," Radiology, 240, 263-272 (2006).
10.1148/radiol.240105071716793983PMC1850234
22
C. Bohris, W. G. Schreiber, J. Jenne, I. Simiantonakis, R. Rastert, H. J. Zabel, P. Huber, R. Bader, and G. Brix, "Quantitative MR temperature monitoring of high-intensity focused ultrasound therapy," Magn. Reson. Imaging. 17, 603-610 (1999).
10.1016/S0730-725X(98)00196-9
23
S. Ebbini, H. Yao, and A. Shrestha, "Dual-mode ultrasound phased arrays for image-guided surgery," Ultrasonic Imaging, 28, 65-82 (2006).
10.1177/01617346060280020117094688
24
A. Anand, D. Savery, and C. Hall, "Three-dimensional spatial and temporal temperature imaging in gel phantoms using backscattered ultrasound," IEEE Trans. Ultrason. Ferroelect. Freq. Contr. 54, 23-31 (2007).
10.1109/TUFFC.2007.20817225797
25
P. D. Bevan and M. D. Sherar, "B-scan ultrasound imaging of thermal coagulation in bovine liver: log envelope slope attenuation mapping," Ultrasound Med. Biol. 27, 379-387 (2001).
10.1016/S0301-5629(00)00358-6
26
P. D. Bevan and M. D. Sherar, "B-scan ultrasound imaging of thermal coagulation in bovine liver: frequency shift attenuation mapping," Ultrasound Med. Biol. 27, 809-817 (2001).
10.1016/S0301-5629(01)00380-5
27
E. E. Konofagou, J. Thierman, T. Karjalainen, and K. Hynynen, "The temperature dependence of ultrasound-stimulated acoustic emission," Ultrasound Med. Biol. 28, 331-338 2002).
10.1016/S0301-5629(01)00525-7
28
R. Seip and E. S. Ebbini, "Noninvasive estimation of tissue temperature response to heating fields using diagnostic ultrasound," IEEE Trans. Biomed. Eng. 42, 828-839 (1995).
10.1109/10.3986447642197
29
V. A. Khokhlova, S. M. Bobkova, and L. R. Gavrilov, "Focus splitting associated with propagation of focused ultrasound through the rib cage," Acoust. Phys. 56, 622-632 (2010).
10.1134/S106377101005012X21607120PMC3098889
30
F. Li, X. Gong, K. Hu, C. Li, and Z. Wanng, "Effect of ribs in HIFU beam path on formation of coagulative necrosis in goat liver," Proc. the 5th International Symposium on Therapeutic Ultrasound. Oxford, UK, 829, 447-480 (2006).
10.1063/1.2205520
31
C. Lafon, V. Zderic, M. L. Nobel, J. C. Yuen, P. J. Kaczkowski, O. A. Sapozhnikov, F. Chavrier, L. A. Crum, and S. Vaezy, "Gel phantom for use in high-intensity focused ultrasound dosimetry," Ultrasound Med. Biol. 31, 1383-1389 (2005).
10.1016/j.ultrasmedbio.2005.06.00416223642
32
B. A. Rabkin, V. Zderic, and S. Vaezy, "Hyperecho in ultrasound images of HIFU therapy: Involvement of cavitation," Ultrasound Med. Biol. 31, 947-956 (2005).
10.1016/j.ultrasmedbio.2005.03.01515972200
Information
  • Publisher :The Acoustical Society of Korea
  • Publisher(Ko) :한국음향학회
  • Journal Title :The Journal of the Acoustical Society of Korea
  • Journal Title(Ko) :한국음향학회지
  • Volume : 39
  • No :1
  • Pages :16-23
  • Received Date : 2019-05-14
  • Accepted Date : 2019-01-10
  • DOI :https://doi.org/10.7776/ASK.2020.39.1.016
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